You can certainly give a sentence which, in effect, expresses a concept close to the negation, but that is a different exercise to giving a correct grammatical transformation of a certain sentence.
In general, to negate, you change "There is ..." to "There is not ...". And to question, you change "There is..." to "Is there ..."
There are often several close enough answers (semantically correct, but not strictly transformed syntactically) - if that's what you need.
Are there any questions you're having specific difficulty with?
"There are some questions you're having specific difficulty with."
"There are no questions you're having specific difficulty with."