Tufguy, you ask a question. If you leave out the word "question", you can ask something of someone. The latter usage is less common.
Nobody is going to shoot you if you use 'of', but it's unnatural.
Okay, we cannot say "I want to ask a question of him" or "I want to ask a question of you" or "he asked a question of me" but we can say "I want to ask this of him".
If somebody asks me something that I am not sure about and I want to confirm it with my father, mother or friend, so can I say to that person "I will have to ask this of my father, mother or friend?"
Bob: When is Sharon coming home?
Rob: I don't know, but my sister knows. I'll ask her.
Have you read posts 5 and 7?
Okay, so it is unnatural to use "of" with or without using the word "question".
If you have a question about the English language and would like to ask one of our many English teachers and language experts, please click the button below to let us know: